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Sibutramine is an appetite suppressant drug that does a great job of lowering cravings and appetite. Needless to mention how effective this is for fat and weight loss goals. That’s why a lot of people use Sibutramine for their cutting and weight loss cycles.

Sibutramine is actually a medication that used to be prescribed to obese people to treat their condition. This is the first medication approved in the USA for obesity treatment, but it was withdrawn from the US market back in October 2010. That’s because, according to studies, it increases cardiovascular problems.

Therefore, this product is great at helping you to lose weight, but it’s a product you should stay away from if you have a history or especially currently have some cardiovascular issues.

People should use Sibutramine in combination with a diet and exercise routine in order to treat obesity. Bodybuilders and athletes use it for the same purpose of burning fat by helping them to stay in a caloric deficit. Of course, alongside their diet plan and workouts.

Important Information About Sibutramine


You should not use Sibutramine if you are taking or have taken an MAO inhibitor in the last 2 weeks. Life threatening side effects can occur if these 2 products interact.

If you’re having an eating disorder (anorexia or bulimia) you shouldn’t use it. Of course, you shouldn’t use Sibutramine if you notice any allergic reactions to it. Suffering from severe high blood pressure or some cardiovascular issues might be a sign that using Sibutramine is not a good idea. Don’t use it in combination with stimulant diet pills or if you have a history of heart disease, stroke, or artery disease.

If you’re healthy enough, you should lose at least 4 pounds during the 4 weeks cycle. Of course, in combination with a proper low calorie diet and exercise plan.


Sibutramine is an active substance. It was sold under the brand name Meridia. Nowadays you can find it as numerous other brand names such as Sibuzone and others. This is an appetite suppressant that helps you lose weight and body fat. That’s what both obese people and athletes use it for, but only in a proper diet and exercise schedule. This way, it should help them consume fewer calories than they are burning.

Studies done on Sibutramine indicate that it’s highly effective at helping patients lose body fat and weight. But then again, it can cause side effects, so you should be highly cautious with it.

Mechanism of Action

Sibutramine is not getting inside the cells to boost the release of serotonin (and other neurotransmitters) unlike most other appetite suppressants. It works outside the cells, as an uptake inhibitor. It stops serotonin norepinephrine reuptake receptors from reabsorbing serotonin. This is what helps you control your appetite.

Why? Because serotonin is a neurotransmitter that controls your mood, your sleeping patterns, and obviously your appetite.

That’s why Sibutramine is likely to affect your mood and sleep too. Same as those antidepressant and ADHD drugs that are containing serotonin inhibiting substances that are popular for affecting mood, sleep, and appetite.


Sibutramine Side Effects

So, you may love the idea that Sibutramine is reducing appetite and you may think that this is exactly what you need for your cutting and weight loss cycle. While it can greatly help, you should first read about its side effects. There are good reasons why it was withdrawn from the US market after all (it’s a schedule IV medication).

First of all, the worst side effects are related to cardiovascular issues. That’s why, having a history of artery disease, stroke or heart disorder is a sign that you may need to stay away from it. If you’re currently having increased heart rate, cardiovascular issues, or high blood pressure – you may need to stay away from it too.

Moreover, Sibutramine is likely to be habit forming. It has the potential for abuse which can lead to limited physical or psychological dependence.

  • Common Sibutramine side effects are insomnia, hands shaking, jittery, headaches, dry mouth, stomach issues, nausea, and numerous others, similar to those of stimulants.

Due to all of these reasons, I strongly recommend starting Sibutramine use at a very low dosage and only increasing it if you’re sure you can deal with the side effects. Take into consideration your current health condition too.


Administering Sibutramine

Sibutramine to lose weight

Sibutramine pills half-life is 14-16 hours. Most effects (peak plasma concentration) are 3-4 hours after the last dosage. Therefore, once a day administration is enough. I strongly recommend using it in the morning. With or without food.

Start at 10 mg/day. Increase to 15 mg/day only if you’re sure you can tolerate this dosage and no sooner than 4 weeks into the 10 mg/day dosage.

Bodybuilders may go for higher doses considering their size and weight.

While prescription Sibutramine was given to patients for up to 2 years, I only recommend using it for 6-8 weeks at a time. Maximum 12 weeks. Given this fact, it’s obvious that side effects risks are much lower.

Where to Buy Sibutramine?

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