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Liothyronine Side Effects

Liothyronine Sodium is a popular weight loss and fat burning compound among athletes and bodybuilders that is very different from all other PEDs such as anabolic steroids or SARMs, but it comes with its own set of side effects. Before you actually use it, I strongly recommend you learn about Liothyronine side effects as much as possible. And in this article that’s exactly what we’re going to talk about.

Considering that Liothyronine is not an anabolic steroid, nor is it a SARM, its side effects are very different. That’s why it is so important to learn about it even if you do have experience with steroids.

What is Liothyronine Sodium?

Liothyronine is a synthetic form of a thyroid hormone known as triiodothyronine (short – T3). Our body (thyroid gland) naturally produces this hormone, but Liothyronine Sodium is the laboratory made version. You could find it as numerous brand/trade names. Yet, the most popular one is Cytomel.

Therefore, when talking about Cytomel (or other brand names containing this chemical substance), Liothyronine, or T3 – we’re talking about pretty much the same thing. Better said, same hormone.


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Liothyronine T3 (Cytomel) is a medication that doctors prescribe to patients that are suffering from hypothyroidism. This is a condition when the thyroid gland is unable to produce enough thyroid hormones. That’s having a negative impact on the body’s metabolism. When the patient uses Liothyronine Sodium, he or she is basically increasing T3 hormone levels leading to normalized metabolism.

In fitness communities, Liothyronine is appealing among athletes and bodybuilders because of its ability to accelerate fat loss by boosting the metabolic rate (via an increase in T3 hormone level). Of course, it offers desired results when the user runs it in combination with a diet that is in a calorie deficit as well as a proper exercise plan.

The thing is that by using Liothyronine your T3 levels increase and if you get too high levels of this hormone, side effects are inevitable. That’s why it’s likely to experience Liothyronine side effects when you use it for fat burning and weight loss purposes. That’s because people tend to use too high dosages leading to too high levels of T3. This leads to the opposite of the hypothyroidism condition – the hyperthyroidism condition (when the body has too much thyroid hormone level).

Hypothyroidism vs Hyperthyroidism

So, hypothyroidism is the condition when you don’t have enough thyroid hormone levels (can occur due to a variety of reasons) and that’s when you normally need Liothyronine T3. Hyperthyroidism is the condition when you have too high a thyroid hormone level. Although also can occur due to a variety of reasons, most commonly it’s because of using too much Liothyronine dosage (or other thyroid hormone medications).

It’s pretty obvious that the higher the dosage, the more likely you are to experience hyperthyroidism. Moreover, it’s also obvious that if you have normal thyroid levels and start using Liothyronine Sodium, you’re also more likely to experience hyperthyroidism symptoms in comparison to a person who starts using it when suffering from hypothyroidism (low thyroid levels).

Therefore, the most common Liothyronine side effects are the symptoms related to high thyroid hormones (hyperthyroidism).

  • Examples of hypothyroidism symptoms are: weight gain, inability to lose weight, lack of energy, poor ability to tolerate cold, and others.
  • Examples of hyperthyroidism (liothyronine side effects) are: the poor ability to tolerate heat (heat sensitivity), anxiety, insomnia, tremors, and others.

In short, you need to make sure you keep T3 levels within normal range and when you use Liothyronine for fitness purposes (weight loss and fat burning) and increase your thyroid hormone levels, you should do it carefully to avoid adverse reactions.


Avoiding Liothyronine Side Effects

Abusing any medication is going to lead to side effects, and Liothyronine Sodium is not an exception. Moreover, it’s important to understand that higher doses of Liothyronine are going to increase the risk of any side effects. It may increase the risk of more serious side effects, some of which may become dangerous!

Cytomel (Liothyronine) is a relatively safe drug, but only when you use it carefully, for proper needs in moderate doses. When you use it for performance needs, you obviously have higher risks. First, because you are not having low thyroid levels (most likely) to start with, and second because you may need higher doses to see the expected results.

Also, please remember that this is a hormone, that’s why it may have different effects on each individual. Pretty much like most other hormonal medications out there. That’s why it’s important to follow your own plan and not anyone else’s. That’s why it is so important to start slowly and increase dosage gradually when you actually need it. Remain at the lowest effective dosage to avoid Liothyronine side effects. Moreover, keep cycles as short as possible because, of course, the longer the cycles, the higher the risks of side effects.

Common Liothyronine Side Effects

The most commonly reported side effects from Liothyronine Sodium T3 are non-serious and usually well tolerated by most people. Usually, they include less tolerance to heat, changes in heartbeat, headaches, increased sweating, changes to bowel function, anxiety, difficulty sleeping (insomnia) as well as menstruation irregularities in women.

  • Not everyone experiences them. Some may not experience any at all. If you do experience these issues, you may experience only a few selected ones. Moreover, some may tolerate them better than others.

liothyronine-side-effects-bodybuilding-t3 Additionally…

In addition to that, it’s important to understand that lethargy or fatigue, and even weakness are sometimes reported. In rare cases, some people report extreme tiredness. Usually, those people who use it in high doses and/or use it for too long cycles without a break in between the cycles.

Moreover, some people may experience muscle loss. That’s because Liothyronine enhances your metabolism. Therefore, everything in the body works harder. Your body needs more energy to meet its demand so it takes it from fat and that’s how you lose weight. But some may experience muscle loss. The body takes its energy demand from muscle tissues. That’s why a lot of people use Liothyronine Sodium (Cytomel T3) alongside anabolic steroids – it allows them to maintain the hard earned lean muscle tissues.

Remember that T3 (Liothyronine) is causing a reduction in ATP. This is what actually leads to lethargy and fatigue (and sometimes to weakness and even extreme tiredness). This is what may lead to reduced muscle performance too, alongside reduced muscle mass. As said, it usually occurs only when you use it in higher doses and/or in longer cycle lengths. Anyway, any of these issues can be a very big problem for bodybuilders and athletes. That’s why they are usually searching for methods to maintain their muscle and enhance their performance while using it (usually, with the help of anabolic steroids).


In addition to that, I should mention that increasing the body temperature is something that you can expect when starting to use this compound. In fact, if the temperature does not increase then it’s possible this compound doesn’t work as it should. That’s because the metabolism is actually relying on body heat (thermogenesis). This is what makes your metabolism work faster, but this is also may be the reason why you could suffer from insomnia, increased sweat, and/or heat sensitivity.

Nonetheless, ensure that the increase in body temperature is not substantial. If it becomes unbearable, it’s a clear sign that you need to reduce the dosage. A too high dosage might increase body temperature and is obviously likely to lead to various issues that can become serious such as chest pain, heart failure, and others.

  • I strongly recommend avoiding using a higher dosage than 125 mcg/day (although Liothyronine side effects risk increasing at a dosage over 50 mcg/day) and do not use it for long periods. Ideally, a dosage over 100 mcg/day shouldn’t ever be attempted. It’s also important to understand that the quality of your diet and exercise will greatly determine the quality of your results, rather than administering higher dosages and/or running longer cycles.

Post Cycle Liothyronine Side Effects

It’s important to understand that by using Cytomel (Liothyronine), the body is becoming dependent on the external source of T3. It is very similar to anabolic steroids suppressing natural testosterone production. So, during the use of Liothyronine, your body’s natural ability to produce T3 decreases. It’s very important to avoid the suppression of T3 by taking lower doses and shorter cycles. Not following a proper plan, can slow down or halt the natural production of the thyroid hormone.

As a result, while you’re likely to experience hyperthyroidism symptoms during the use of Liothyronine (especially if you attempt higher dosages), you’re likely to experience hypothyroidism symptoms after the cycle of Liothyronine. That’s because your body doesn’t produce yet normal amounts of T3 and you do not supply it exogenously (since you stop using Liothyronine).

  • Of course, the higher dosages and/or longer cycle length – the higher the suppression. Therefore, the more time your body needs to recover. In case of abuse, it may remain permanently suppressed.
  • To avoid such issues, I strongly recommend a slow reduction of Liothyronine dosage toward the end of a cycle.

Such as reducing to 25 mcg/day for the last 1-2 weeks and may even reduce to 12.5 mcg/day for the last week before completely stopping. That’s allowing your body to adjust to the newer dosage and restart the production of T3, rather than suddenly stopping from a higher dosage and possibly long cycle.

  • Moreover, you could try supplementing yourself with various natural compounds and elements that could assist a faster T3 production recovery. Some of them include zinc, ashwagandha, selenium, vitamin B12, iodine, magnesium, iron, vitamin D, antioxidants, L tyrosine, and others. Supplementing yourself with at least a few of these may be helpful.

Liothyronine Side Effects Conclusion

In the end, you need to learn how to use it correctly. As long as you want to use Liothyronine Sodium and avoid its side effects. You’ve got to use it in the proper dosage. 25-75 mcg/day are the most common. 100-125 mcg/day are the highest dosages. Also, proper cycle length. 4-8 weeks are most common. 12 weeks is the longest you can attempt).

Moreover, remember that you may add anabolic steroids to avoid muscle loss. Additionally, you may attempt slow dosage reduction toward the end of the cycle to avoid withdrawal symptoms (hypothyroidism). Lastly, make sure you work out and diet correctly for yielding the best results.

One more thing that you should be aware of is the fact that you need high quality Liothyronine Sodium, of course, for it to work correctly. Lower quality stuff may not be as effective, but worse – may cause more side effects.

At you can both learn how to use Cytomel and buy Liothyronine for sale of the highest quality. This way you can use it correctly and get the best results while avoiding the Liothyronine side effects.


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